报告题目：Dendronization of Macromolecules to Afford Unprecedented Thermoresponsiveness

报告人：张阿方（上海大学）  

报告时间：2018年5月25日（星期五）下午 15:00

报告地点：材料与化学化工学部907幢1445室

摘要：

 This presentation will discuss our findings in developing versatile thermoresponsive macromolecules by decorated with OEG moieties through covalent linkages, dynamic covalent linkages or supramolecular interactions. Through dendronization with these OEGylated dendrons, these macromolecules can be afforded with unprecedented thermoresponsive properties, including fast and sharp phase transitions and small hysteresis. OEGylated (amphiphilic) dendronized polymers, helical polymers, polypeptides, cyclodextrins, as well as fluorescence dyes will be discussed in detail. Based on the thickness effects, dendronized polymers undergo heterogeneous dehydration and collapse, which results interestingly in the formation of molecular containers. Besides, guest molecules can be encapsulated and released according to temperature, heating rate and thickness of the polymers. Depending mainly on the molecular topology, amphiphilic structure plays different roles on mediating the thermoresponsive properties of dendritic macromolecules. OEGylated helical polymers can be thermally induced to aggregation, and their helical conformation can be tuned accordingly. OEGylated polypeptides show excellent thermoresponsive properties, and their secondary structures can be altered simultaneously through reversible dehydration. OEGylated cyclodextrins show thermoresponsiveness depending on their ring sizes and OEG lengths. Notably, these thermoresponsive cyclodextrin derivatives inherit inclusion ability from their parent representatives, which can be tuned through temperature. Furthermore, these thermoresponsive entities have also been devoted to acting as colorimetric or fluorescence sensors to solution pH and/or temperature with remarkable sensibility.

个人简介：

   张阿方，上海大学特聘教授，上海市特聘专家、“千人”教授，入选2011年度浦江人才计划，2017年起被昆士兰大学授予荣誉教授，曾任瑞士苏黎世联邦理工大学资深研究员。从合肥工业大学获得本科、中国科技大学硕士学位、北京大学博士学位，德国柏林自由大学博士后研究。主持承担（完成）国家自然科学基金委重点及面上项目、瑞士国家自然科学基金项目及国家“八五”重点科技攻关项目等三十余项课题，科研成果获省部级二等奖四项、三等奖多项。二十余种国际著名刊物审稿人，Molecules及Current Organic Chemistry客座编辑。近年来在包括Adv. Mater., Angew. Chem., Chem. Commun., Macromolecules, Nat. Commun.和J. Am. Chem. Soc.等国际著名刊物上发表学术论文120余篇，在德国 Wiley出版社、Springer出版社及英国皇家化学会合著专著6部。主要从事树枝化聚合物及智能螺旋聚合物等方面的研究。

欢迎广大师生参加！

                                                                                       （报告联系人：张伟老师）