报告题目：Block Copolymer Crystalsomes --- Vesicles with Ultrathin Shell to Extend Blood Circulation Time
报告人：Christopher Y. Li（Department of Materials Science and Engineering, Drexel University, United States）
报告时间：2018年08月02日（周四）上午09:30
报告地点：独墅湖校区911号楼406报告室
欢迎广大师生踊跃参加。
报告摘要：
In water, amphiphilic block copolymers (BCPs) can self-assemble into various micelle structures depicting curved liquid/liquid interface. Crystallization, which is incommensurate with this curved space, often leads to defect accumulation and renders the structures leaky, undermining their potential biomedical applications. In this talk, I will discuss using an emulsion-solution crystallization method to control the crystallization of an amphiphilic BCP at curved liquid/liquid interface. The resultant BCP crystalsomes (BCCs) structurally mimic the classical polymersomes and liposomes yet mechanically are more robust thanks to the single crystal-like crystalline PLLA shell. In contrary to classical polymersomes, these BCCs are nearly impermeable to hydrophilic and hydrophobic drugs. In blood circulation and biodistribution experiments, fluorophore-loaded BCCs show a prolonged circulation half-life. We further demonstrate this excellent performance is attributed to controlled polymer crystallization and the unique BCC nanostructure.
Christopher Y. Li（李育人）教授简介：
Christopher Y. Li教授主要从事高分子物理和材料方面的研究，目前为美国Drexel University终身教授，美国物理学会会士（American Physical Society Fellow）。1991-1995，中国科技大学，本科；1995-1999，美国阿克伦大学（The University of Akron）高分子科学与工程系，博士；2000-2001，阿克伦大学高分子科学与工程系博士后研究员；2002-2007，Drexel University材料科学与工程系助理教授（Assistant Professor）；2007-2011，Drexel University材料科学与工程系副教授（Associate Professor）；2011-迄今，Drexel University材料科学与工程系教授。在顶级国际期刊Nat. Mater., Nat. Nanotechnol., J. Am. Chem. Soc., Adv. Mater., Phys. Rev. Lett., Macromolecules等杂志发表学术论文120多篇，参与撰写专著15本，文章被引用次数超过3000次，H因子35。获各种奖励21项。为Nature、Nature Materials等杂志审稿人，受邀举办学术讲座110余次。其工作被NSF, the Royal Chemical Society, American Chemical Society, ASM International, Physical Review Focus等杂志或媒体报道。于2003年获得美国的NSF-CAREER Award，2006年获得中国的海外杰青，2011年获得NSF Special Creativity Award，2012年当选为美国物理学会会士，2014年当选为北美热分析学会会士，2016年获得Inaugural Provost’s Award for Outstanding Mid-Career Scholarly Achievement。
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