题目：From Single-chain Digital Polymers to Organized Coded Matter
Université de Strasbourg, France
地点：独墅湖炳麟图书馆学术报告厅
时间：2018年9月26日(周三)9:30-11:00
摘要：
It has been shown in recent years that information can be stored at the molecular level in synthetic polymers [1, 2]. To achieve such a property, different comonomers are used as a molecular alphabet and assembled together into a defined information sequence [3]. For instance, an alphabet based on two different monomers allows writing of binary information in a linear polymer chain [4]. But of course such digital polymers cannot be synthesized using a standard chain-growth or step-growth polymerization mechanisms because these approaches lead to polydisperse samples containing pronounced sequence defects. Instead, so-called multi-step growth strategies have to be employed [5]. For instance, solid-phase iterative chemistry allows synthesis of a wide variety of uniform sequence-defined digital polymers [3, 5]. This approach is not restricted to oligomers and long digital chains containing more than 100 coded residues have been prepared [6]. Moreover, the information stored in these chains can be easily decoded by tandem mass spectrometry. As shown very recently, not only short but also long digital sequences can be deciphered using this analytical technique [7]. Furthermore, a sequencing software allows decryption in some milliseconds [8].
Since multi-byte digital encryption and decryption of a synthetic polymer chain has now been clearly demonstrated, the next important challenge in this emerging field of research will be the application of such digital polymers in technological areas; for example for the development of molecular memories. However, such applications are quite demanding and imply to move from simple proofs-of-concept at the single-chain level to complex multi-chain libraries allowing storage and manipulation of larger amounts of information. In this lecture, I will highlight new directions that are currently under investigation in my laboratory for the development of such complex “coded matter”. In particular, I will describe simple strategies for the preparation of polymer materials allowing high-density information storage. Specific emphasis will be put on the development of planar digital micro-arrays and on the three-dimensional crystallization behavior of digital polymers.
个人简介：
2009 Habilitation - Universität Potsdam, Germany
2000 Ph.D. (Diplôme de docteur) - Université Montpellier II, France
1996 M.Sc. (Diplôme d’études approfondies, DEA) - Université Paris VI, France
1995 B.Sc. (Maîtrise de Chimie) - Université Paris VI, France
He has published 215 peer-reviewed publications, book chapters and patents (list available on request). Total number of citations > 12500, h-index = 54 (source: Web of Science); Listed since 2015 as a ISI Highly Cited Researcher in the category “Chemistry”.
Selected Publications：
2017 A. Al Ouahabi, J.-A. Amalian, L. Charles, J.-F. Lutz, Nature Communications, 8:967.
2016 J.-F. Lutz, J.-M. Lehn, E. W. Meijer, K. Matyjaszewski, From Precision Polymers to Complex Materials and Systems, Nature Reviews Materials, 1, 16024.
2015 R. K. Roy, A. Meszynska, C. Laure, L. Charles, C. Verchin, J.-F. Lutz, Design and synthesis of digitally-encoded polymers that can be decoded and erased, Nature Communications, 6:7237.
2014 H. M. Colquhoun, J.-F. Lutz, Information-containing Macromolecules, Nature Chemistry, 6, 455-456.
2013 J.-F. Lutz, M. Ouchi, D. R. Liu, M. Sawamoto, Sequence-controlled Polymers, Science, 341, 1238149.
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