Palladium-Catalyzed Carboxylate-Assisted Ethoxycarboxylation of Aromatic Acids To Synthesize Monoethyl Phthalate Derivatives with Ethyl Bromodifluoroacetate

Na Tao, Jie Wang, Chunchen Yuan, Runsheng Zeng^*（曾润生）, and Ying-Sheng Zhao^* （赵应声）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Org. Lett.2019, 21, 8607--8610

A novel and efficient approach for direct carbonation of aromatic acids with ethyl bromodifluoroacetate as the carbonyl source is reported. A broad range of substrates bearing various functional groups were tolerated, leading to monoalkyl phthalate derivatives in moderate to good yields.

链接：https://pubs.acs.org/doi/10.1021/acs.orglett.9b03196