Palladium-catalyzed regioselective hydrofunctionalization of methylenecyclopropanes (MCPs) with azaaryl alcohols as latent C(sp3)-nucleophiles
Peng Hao-Yu1,2, Ji Shun-Jun(纪顺俊)1,2*, Cai Zhong-Jian(蔡忠建)1,2*
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science,Soochow University, Suzhou, 215123, China
2Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China
Chem. Commun.2026, 62, 13619-13623
Abstract: Herein, we report a palladium-catalyzed regioselective hydrofunc tionalization of methylenecyclopropanes (MCPs). The reaction uses azaaryl alcohols as methyl azaarene surrogates and proceeds smoothly with a wide variety of mono- and di-substituted MCPs. A range of terminal alkene fragments were introduced to the a-carbon of azaarenes successfully. The reaction is characterized by good yields, high regioselectivity, and broad substrate scope.
Article information: https://doi.org/10.1039/d6cc02809h
