Merging Distal Alkynyl Migrationand PhotoredoxCatalysis for Radical TrifluoromethylativeAlkynylation of Unactivated Olefins
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu, China
2School of Materials Science and Engineering, Sun Yat-sen University, Guangdong, China
Angew.Chem.Int.Ed.2017,56,4545–4548
Disclosed herein is a novel, redox-neutral protocol for the visible-light-induced radical alkynylation of unactivated olefins. The intramolecular migration of an alkynyl group, by cleaving an inert C−C σ bond, is realized for the first time. A wide range of synthetically useful trifluoroethylated linear alkynes are readily obtained under mild reaction conditions.
链接：http://onlinelibrary.wiley.com/doi/10.1002/anie.201700413/abstract
