Cobalt-Catalyzed Isocyanide-Based Three-Component Cascade for the Synthesis of Quinazolines

Shuai Jiang, Wen-Bin Cao, Xiao-Ping Xu^*（徐小平）, and Shun-Jun Ji*（纪顺俊）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China

Org. Lett. 2021, 23, 6740--6744

A Co-catalyzed cyclization reaction of isocyanides, azides, and amines to access quinazoline derivatives was described. This protocol features a high atom economy, mild reaction conditions, excellent yields, and a broad substrate scope. This cascade reaction involved three or four C–N bonds and the formation of one or two rings. The quinazolin-4(H)-imines obtained are proven to be versatile intermediates for further valuable transformations. It was also found that the cobalt catalyst could be isolated from the reaction mixture and reused.

链接：https://pubs.acs.org/doi/10.1021/acs.orglett.1c02316