李新明
  姓名:李新明
  职称:教授,博士生导师
  部门:材料学院
  联系方式:

Email: xinmingli@suda.edu.cn

 
 课题组网站

学历及学术经历:19986月毕业于北京化工大学高分子材料科学与工程专业,获工学学士学位;20036月毕业于北京化工大学材料学专业,获工学硕士学位; 20086月毕业于新加坡国立大学化学专业;获理学博士学位。20087-20092月和20093-20126月,分别在新加坡南洋理工大学的化学与化学生物学系和美国Brandeis University化学系从事博士后研究工作,20128月受聘于苏州大学材料化学与化工学部教授。

 

研究工作和成果主要从事构建具有良好生物医学应用潜力的多肽超分子自组装纳米凝胶材料。主持科技部国家重点研发计划子课题项目,国家自然科学基金面上项目,江苏省自然科学基金面上项目,教育部留学回国人员科研启动基金,苏州市科技创新政策性资助。 2015年获得苏州大学东吴学者计划资助。已在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Biomaterials, Chem. Sci., Chem. Commun., J. Mater. Chem. B, ACS Appl. Mater. Interfaces, Adv. Healthcare Mater.等国际核心研究期刊上发表论文60余篇。

 

研究方向:(1) 纳米自组装材料,(2)生物医用凝胶

 

科研项目:

  1. 基于天然细胞外基质的智能人工血管原位再生机制研究,2016YFC1100105科技部国家重点研发计划2016-2020

  2. 基于糖肽分子自组装构建新型细胞支架材料和抑菌材料的研究,51673142,国家自然科学基金,2017-2020

  3. 抗酶解功能型仿生多肽自组装软物质纳米材料,21344002,国家自然科学基金,2014

  4. 构建具有抑菌和抗酶解特性的仿生多肽自组装水凝胶的研究,BK20151218,江苏省自然科学基金,2015-2018

  5. 糖苷酶启动糖肽超分子自组装水凝胶的研究,教育部留学回国人员科研启动基金

 

授权专利:

  1. 李新明,程宝昌,一种生理条件下蚕丝蛋白溶液快速凝胶化的方法,ZL201711143052.42019422日,中国发明专利

  2. 李新明,刘洁,一种抗菌水凝胶因子及其制备方法用途,ZL201510120256.02018824日,中国发明专利


代表性论文:

[1] Lianlian Wang, Zhijie Chen, Yufei Yan, Chuan He, Xinming Li*, Fabrication of injectable hydrogels from silk fibroin and angiogenic peptides for vascular growth and tissue regeneration, Chem. Eng. J., 2021, 418, 129308

[2] Hang Li, Jikun Zhang, Shengnan Liu, Yufei Yan* and Xinming Li*, Consecutive dephosphorylation by alkaline phosphatase-directed in situ formation of porous hydrogels of SF with nanocrystalline calcium phosphate ceramics for bone regeneration, J. Mater. Chem. B, 2020, 8, 9043-9051

[3] Shengnan Liu, Hang Li, Jikun Zhang, Xin Tian* and Xinming Li*, A biocompatible supramolecular hydrogel with multivalent galactose ligands inhibiting Pseudomonas aeruginosa virulence and growth, RSC Adv., 2020, 10, 33642

[4] Jikun Zhang, Shengnan Liu, Hang Li, Xin Tian*, and Xinming Li*, Tryptophan-Based Self-Assembling Peptides with Bacterial Flocculation and Antimicrobial Properties, Langmuir 2020, 36, 38, 11316–11323

[5] Ya Yang, Hui Wang*, Jia-Chen Zhu, Yun-Fei Shao, Feng-Jiao Bai, Xiao-Min Chen, Xinming Li, Mingyu Guo, Zengwu Shao, and Ke-Qin Zhang,* Silk-Fibroin-Assisted Cathodic Electrolytic Deposition of Calcium Phosphate for Biomedical Applications, ACS Biomater. Sci. Eng. 2019, 5, 9, 4302–4310

[6] Juan Jing, Shufeng Liang, Yufei Yan, Xin Tian and Xinming Li,* Fabrication of Hybrid Hydrogels from Silk Fibroin and Tannic Acid with Enhanced Gelation and Antibacterial Activities, ACS Biomater. Sci. Eng. 2019, 5, 9, 4601–4611

[7] Jing Li, Shufeng Liang, Yufei Yan, Xin Tian, Xinming Li,* O-Mannosylation Affords a Glycopeptide Hydrogel with Inherent Antibacterial Activities against E. coli via Multivalent Interactions between Lectins and Supramolecular Assemblies, Macromol. Biosci. 2019, 19, 1900124

[8] Yufei Yan, Baochang Cheng, Kaizhe Chen, Wenguo Cui, Jin Qi,* Xinming Li,* and Lianfu Deng “Enhanced Osteogenesis of Bone Marrow-Derived Mesenchymal Stem Cells by a Functionalized Silk Fibroin Hydrogel for Bone Defect Repair” Adv. Healthcare Mater. 2018, 1801043.

[9] Baochang Cheng, Yufei Yan, Jingjing Qi, Lianfu Deng, Zeng-Wu Shao, Ke-Qin Zhang, Bin Li, Ziling Sun, and Xinming Li*, “Cooperative Assembly of a Peptide Gelator and Silk Fibroin Afford an Injectable Hydrogel for Tissue Engineering” ACS Appl. Mater. Interfaces, 2018, 10, 12474–12484.

[10] Jingjing Qi, Yufei Yan, Baochang Cheng, Lianfu Deng, Zengwu Shao, Ziling Sun, and Xinming Li*, “Enzymatic Formation of an Injectable Hydrogel from a Glycopeptide as a Biomimetic Scaffold for Vascularization” ACS Appl. Mater. Interfaces, 2018, 10, 6180–6189.

[11] Qingxin Yao, Qiang Bao, Xinming Li, Hui Wang, Zhenyu Yang, Xinghua Shi*, Yuan Gao* and Bing Xu, “Determination of the packing model of a supramolecular nanofibervia mass-per-length measurement and de novo simulation” Nanoscale, 2018, 10, 3990-3996.

[12] Fengyang Xu, Jie Liu, Jian Tian, Linfeng Gao, Yue Pan, Ziling Sun* and Xinming Li*, “Supramolecular Self-assemblies with nanoscale RGD clusters promote cell growth and intracellular drug delivery” ACS Appl. Mater. Interfaces, 2016, 8, 29906–29914.

[13] Jie Liu, Ziling Sun, Yuqi Yuan, Xin Tian, Xi Liu, Guangxin Duan, Yonggang Yang, Lin Yuan,* Hsin-Chieh Lin,* and Xinming Li* , “Peptide Glycosylation Generates Supramolecular Assemblies from Glycopeptides as Biomimetic Scaffolds for Cell Adhesion and Proliferation” ACS Appl. Mater. Interfaces, 2016, 8, 6917–6924.

[14] Jie Liu, Fengyang Xu, Ziling Sun,* Yue Pan, Jian Tian, Hsin-Chieh Lin, Xinming Li*, “A supramolecular gel based on a glycosylated amino acid derivative with the property of gel to crystal transition” Soft Matter, 2016, 12, 141-148.

[15] Jingwen Li, Zhonglin Lv, Yanli Li, Huan Liu, Jinkui Wang, Hong Chen*, Huabing Chen* and Xinming Li*, “Combined Photothermal-Chemotherapy by Pt Conjugated PEGylated Nano-Graphene Oxide for Synergistic Enhancement of Antitumor Efficacy of Pt Drug” Biomaterials, 2015, 51, 12-21.

[16] Hongmei Zhang, Chenglong Xu, Jie Liu, Xiaohong Li, Lin Guo* and Xinming Li*, “A Latent Probe for Rapid and Sensitive Alkaline Phosphatase Detection and Imaging in Living Cells through Enzyme-Triggered Cascade Reaction” Chem. Commun., 2015, 51, 7031-7034.

[17] Huan Liu, Yanli Li, Zhonglin Lyu, Yingbo Wan, Xiaohong Li, Huabing Chen, Hong Chen and Xinming Li*, ” Enzyme-triggered supramolecular self-assemblies of platinum prodrug with enhanced tumor-selective accumulation and reduced systemic toxicity” J. Mater. Chem. B, 2014, 2, 8303-8309.

[18] Xiaojing Wang, Huan Liu, Jingwen Li, Kaiguo Ding, Zhonglin Lv, Yonggang Yang, Hong Chen*, Xinming Li*, “A Fluorogenic Probe with Aggregation-Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers” Chemistry –Asian J., 2014, 3, 784-789.

[19] Jiaqing Wang,  Lei Hu,  Xueqin Cao,  Jianmei Lu,  Xinming Li* and   Hongwei Gu*, “Catalysis by Pd nanoclusters generated in situ of high-efficiency synthesis of aromatic azo compounds from nitroaromatics under H2 atmosphere” RSC Adv., 2013, 3, 4899-4902.

[20] Huan Liu, Zhonglin Lv, Kaiguo Ding, Xiaoli Liu, Lin Yuan, Hong Chen* and Xinming Li*, ” Incorporation of tyrosine phosphate into tetraphenylethylene affords an amphiphilic molecule for alkaline phosphatase detection, hydrogelation and calcium mineralization” J. Mater. Chem. B, 2013, 1, 5550-5556.

[21] Jiaqing Wang, Xinming Li*, Hongwei Gu*, “Understanding the Atomic-scale Process of Catalytic Assembly of Si Nanowires through Al Injection” ChemCatChem, 2013, 5, 2802-2804.

[22] Jingwen Li, Xinming Li*, Xiujuan Shi, Xuewen He, Wei Wei, Nan Ma* and Hong Chen, “Highly Sensitive Detection of Caspase-3 Activities via a Nonconjugated Gold Nanoparticle-Quantum Dot Pair Mediated by an Inner-Filter Effect” ACS Appl. Mater. Interfaces, 2013, 5, 9798-9802.

[23] Xinming Li, Xuewen Du, Jiayang Li, Yuan Gao, Yue Pan, Junfeng Shi, Ning Zhou and Bing Xu*, “Introducing a D-amino acid or a simple glycoside into small peptides to enable supramolecular hydrogelators to resist proteolysis” Langmuir, 2012, 28, 13512–13517.

[24] Xinming Li, Xuewen Du, Yuan Gao, Junfeng Shi, Yi Kuang, Bing Xu*, “Supramolecular hydrogels formed by the conjugates of nucleobases, Arg-Gly-Asp (RGD) peptides, and glucosamine” Soft Matter, 2012, 8, 7402 – 7407.

[25] Xinming Li, Yi-Kuang, Bing Xu*, “Molecular trinity for soft materials: Integrating nucleobases, amino acids, and glycosides, to construct multifunctional hydrogelators” Soft Matter, 2012, 8, 2801-2806.

[26] Xinming Li, Yi-Kuang, Hsin-Chieh Lin, Junfeng Shi, Yuan Gao, Bing Xu*, “Multifunctional, biocompatible supramolecular hydrogelators only consist of nucleobase, amino acid, and glycoside” J. Am. Chem. Soc., 2011, 133, 17513-17518.

[27] Xinming Li, Yi-Kuang, Hsin-Chieh Lin, Yuan Gao, Junfeng Shi, and Bing Xu*, “Supramolecular nanofibers and hydrogels of nucleopeptides” Angew. Chem. Int. Ed., 2011, 50, 9365-9369.

[28] Xinming Li, Jiayang Li, Yuan Gao, Yi-Kuang, Junfeng Shi and Bing Xu*, “Molecular nanofibers of olsalazine form supramolecular hydrogels for reductive release of an anti-inflammatory agent” J. Am. Chem. Soc., 2010, 132, 17707-17709.

[29] Xinming Li, Yuan Gao, Yi-Kuang and Bing Xu*, “Enzymatic formation of a photoresponsive supramolecular hydrogel” Chem. Commun, 2010, 46, 5364-5366.

[30] Xinming Li, Magdeline Tao Tao Ng, Yifan Wang, Tianyan Zhou, Sock Teng Chua, WeixinYuan and Tianhu Li, “Site-specific self-cleavage of G-quadruplexes formed by Oxytricha telemetric repeats” Aust. J. Chem., 2009, 62, 1189-1193.

[31] Tianyan Zhou, Xinming Li*, Yifan Wang, Magdeline Tao Tao Ng, Sock Teng Chua, Ngee Mien Quek, Zhaoqi Yang, Ji Luo, Weixing Yuan and Tianhu Li, “Synthesis and characterization  of circular structures of i-motif tagged with fluoresceins” Bioconjugate Chem., 2009, 20, 644-647.

[32] Xinming Li, Magdeline Tao Tao Ng, Yifan Wang, Tianyan Zhou, Sock Teng Chua, Weixing Yuan and Tianhu Li,* “Site-specific self-cleavage of G-quadruplexes formed by human telometric repeats” Bioorg. Med. Chem. Lett., 2008, 18, 5576-5580.

[33] Xinming Li, Magdeline Tao Tao Ng, Yifan Wang, Xiaoqian Liu and Tianhu Li,* “Dumbbell-shaped circular oligonucleotides as human topoisomerase I inhibitors”, Bioorg. Med. Chem. Lett., 2007, 17, 4967-4971.