Directing-Group-Free C7-Alkylations of N-Alkylindoles Mediated by Cationic Zirconium Complexes: Role of Brønsted Acid for Catalytic Manifold
Ping Chen[a], Yanhong Hao[a],Xinxin Wang[a], Dan Yuan*[a](袁丹), Yingming Yao*[a](姚英明), and Lutz Ackermann*[b]
[a] Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science Soochow University, Suzhou 215123 (P. R. China)
[b] Institut fer Organische und Biomolekulare Chemie Georg-August-Universi-t Gçtingen Tammannstraße 2, 37077 Gçtingen (Germany)
Chem. Eur. J. 2019, 25, 7292--7297
Highly position selective alkylations of N‐alkylindoles at C7‐positions have been enabled by cationic zirconium complexes. The strategy provides a straightforward access to install alkyl groups at C7‐positions of indoles without a complex directing group. Mechanistic studies provided support for the importance of Brønsted acids in the catalytic manifold.
链接:https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201901268