Binary tree-inspired digital dendrimer
Zhihao Huang1 , Qiunan Shi1 , Jiang Guo 2, Fanying Meng1 , Yajie Zhang1 , Yutong Lu1 , Zhuangfei Qian1 , Xiaopeng Li 3, Nianchen Zhou1 , Zhengbiao Zhang 1,*（张正彪） & Xiulin Zhu1,4
1 College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123 Suzhou, China.
2 Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
4 Global Institute of Software Technology, No. 5. Qingshan Road, Suzhou National Hi-Tech District, 215163 Suzhou, China.
NATURE COMMUNICATIONS， (2019) ，10:1918
Digital polymers with precisely ordered units acting as the coded 0- or 1-bit, are introduced as a promising option for molecular data storage. However, the pursuit of better performance in terms of high storage capacity and useful functions never stops. Herein, we propose a concept of an information-coded 2D digital dendrimer. The divergent growth via thiol-maleimide Michael coupling allows precise arrangements of the 0- and 1-bits in the uniform dendrimers. A protocol for calculating the storage capacity of non-linear binary digital dendrimer is established based on data matrix barcode, generated by the tandem mass spectrometry decoding and encryption. Furthermore, the generated data matrix barcode can be read by a common hand-held device to cater the applications such as item identification, traceability and anticouterfeiting purpose. This work demonstrates the high data storage capacity of a uniform dendrimer and uncovers good opportunities for the digital polymers.