[3 + 3]-Cycloaddition of α‑Diazocarbonyl Compounds and N‑Tosylaziridines: Synthesis of Polysubstituted 2H‑1,4-Oxazines through Synergetic Catalysis of AgOTf/Cu(OAc)2

Shangwen Fang, Yanwei Zhao, Haiyan Li, Yonggao Zheng, Pengcheng Lian, and Xiaobing Wan^*（万小兵）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P.R. China

Org. Lett.2019, 21, 2356--2359

An impressive and new [3 + 3]-cycloaddition of α-diazocarbonyl compounds with N-tosylaziridines via synergetic catalysis of AgOTf and Cu(OAc)₂ has been well described, which offers efficient access to highly substituted 2H-1,4-oxazine derivatives. A variety of α-diazocarbonyl compounds and N-tosylaziridines were compatible substrates with convenient operations under mild reaction conditions.

链接：https://pubs.acs.org/doi/10.1021/acs.orglett.9b00632