Interception of Radicals by Molecular Oxygen and Diazo Compounds: Direct Synthesis of Oxalate Esters Using Visible-Light Catalysis

Meihua Ma, Weiwei Hao, Liang Ma, Yonggao Zheng, Pengcheng Lian, and Xiaobing Wan^*（万小兵）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China

Org. Lett., 2018, 20 (18), 5799--5802

The synthesis of oxalate esters through a radical process, rather than the traditional ionic reaction, has been well developed in which the radicals induced by visible light are trapped by molecular oxygen and diazo compounds under room temperature. This reaction is operationally simple, mild, and shows broad substrate scopes in α-bromo ketones and diazo compounds.

链接：https://pubs.acs.org/doi/10.1021/acs.orglett.8b02487