| Name：ZHONG Zhiyuan|
Professor (Biomedical Polymers)
B.Sc. Jilin University of Technology (1991-1995)
M.Sc. Changchun Institute of Applied Chemistry,
Chinese Academy of Sciences (1995-1998)
Ph.D. University of Twente (1998-2002)
Assistant Professor, University of Twente (2002-2007)
Education and Work Experiences:
His research focuses on design and development of functional biodegradable polymers, stimuli-sensitive drug and protein delivery systems, and targeted nanomedicines. He has co-authored more than 110 papers with over 5300 times of citation (H-Index 41). His two papers have been recognized as "Top 100 Most Cited Chinese Papers Published in International Journals" (2010 and 2011) by the Instituteof Scientific and Technical Information of China. In the past five years, he has delivered more than 40 invited lectures in the international conferences. He has been served as an Editorial/Advisory Board Member of Biomacromolecules (ACS), Journal of Controlled Release (Elsevier), Journal of Materials Chemistry B (RSC), and Journal of Biomaterials Science, Polymer Edition (Talor & Francis), a Promotion Editor ofSCIENCE CHINA Chemistry (Springer), an Executive Chair of The 1st, 2nd and 3rdSymposium on Innovative Polymers for Controlled Delivery (SIPCD 2010, 2012 and 2014, Suzhou, China), a Co-Chair of Multifunctional Biomaterials Symposium of MRS 2013 Spring Meeting (San Francisco), a Guest Editor for Journal of Controlled Release (2011 and 2013), and a member of Grant Review Panel of the National Natural Science Foundation of China (NSFC) as from 2012.
He has received several prestigious awards, including the Biomacromolecules/Macromolecules Bessel Research Award from the Alexander von Humboldt Foundation (2013), Award for Breakthrough Technologies in Drug Delivery Systems in Asia from the Japanese Society of Drug Delivery System (2013), Jiangsu Province-Endowed Professorship (2013), Award for Top 10 Most Charming Scientist in Suzhou City (2013), and Outstanding Young Scholar Award from the National Natural Science Foundation of China (NSFC, 2012).
Biomedical polymers; controlled drug and protein delivery; non-viral gene delivery; targeted cancer therapy.
1. Y.J. Jiang, J. Chen, C. Deng*, E. Suuronen, and Z.Y. Zhong*, Click Hydrogels, Microgels and Nanogels: Emerging Platforms for Drug Delivery and Tissue Engineering, Biomaterials2014, http://dx.doi.org/10.1016/j.biomaterials.2014.03.001.
2. C. Deng, J.T. Wu, R. Cheng, F.H. Meng, H.A. Klok, and Z.Y. Zhong*, Functional Polypeptide and Hybrid Materials: Precision Synthesis via α-Amino Acid N-Carboxyanhydride Polymerization and Emerging Biomedical Applications, Prog. Polym. Sci.2014, 39,330-364.
3. W. Chen, Y. Zou, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Glyco-Nanoparticles with Sheddable Saccharide Shells: A Unique and Potent Platform for Hepatoma-Targeting Delivery of Anticancer Drugs, Biomacromolecules 2014, 15, 900-907.
4. Y.N. Zhong, W.J. Yang, H.L. Sun, R. Cheng, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells, Biomacromolecules 2013, 14, 3723-3730.
5. J.R. Zhou, P.P. Chen, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, A Simple and Versatile Synthetic Strategy to Functional Polypeptides via Vinyl Sulfone-Substituted L-Cysteine N-Carboxyanhydride, Macromolecules 2013, 46, 6723–6730.
6. Y.P. Fan, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, In Situ Forming Hydrogels via Catalyst-Free and Bioorthogonal “Tetrazole–Alkene” Photo-Click Chemistry,Biomacromolecules 2013, 14, 2814-2821.
7. X.Y. Wang, H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier To Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells,Biomacromolecules 2013, 14, 2873-2882.
8. Y.D. Gu, Y.N. Zhong, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Acetal-Linked Paclitaxel Prodrug Micellar Nanoparticles as a Versatile and Potent Platform for Cancer Therapy, Biomacromolecules 2013, 14, 2772-2780.
9. Y.N. Zhong, W. Wang, L. Cheng, F.H. Meng, Z.Y. Zhong*, and Z. Liu*, Gold Nanorod-Cored Biodegradable Micelles as a Robust and Remotely Controllable Doxorubicin Release System for Potent Inhibition of Drug-Sensitive and -Resistant Cancer Cells,Biomacromolecules 2013, 14, 2411-2419.
10. L.L. Wu, Y. Zou, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Intracellular Release of Doxorubicin from Core-Crosslinked Polypeptide Micelles Triggered by Both pH and Reduction Conditions, Biomaterials 2013, 34, 5262-5272.
11. W. Chen, M. Zheng, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, In SituForming Reduction-Sensitive Degradable Nanogels for Facile Loading and Triggered Intracellular Release of Proteins, Biomacromolecules 2013, 14, 1214-1222.
12. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction-Sensitive Degradable Micellar Nanoparticles as Smart and Intuitive Delivery Systems for Cancer Chemotherapy, Expert Opin. Drug Deliv. 2013, 10, 1109-1122.
13. R. Cheng, F.H. Meng, C. Deng, H.A. Klok, and Z.Y. Zhong*, Dual and Multi-Stimuli Responsive Polymeric Nanoparticles for Programmed Site-Specific Drug Delivery,Biomaterials 2013, 34, 3647-3657.
14. W. Chen, P. Zhong, F.H. Meng*, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Redox and pH-Responsive Degradable Micelles for Dually Activated Intracellular Anticancer Drug Release, J. Control. Release 2013, 169, 171-179.
15. W. Chen, Y. Zou, J.N. Jia, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Functional Poly(ε-caprolactone)s via Copolymerization of ε‑Caprolactone and Pyridyl Disulfide-Containing Cyclic Carbonate: Controlled Synthesis and Facile Access to Reduction-Sensitive Biodegradable Graft Copolymer Micelles, Macromolecules 2013, 46, 699-707.
16. F.H. Meng, R. Cheng, C. Deng, and Z.Y. Zhong*, Intracellular Drug Release Nanosystems,Materials Today 2012, 15, 436-442 (invited review)
17. Y.L. Wu, W. Chen, F.H. Meng, Z.J. Wang, R. Cheng, C. Deng, H.Y. Liu, and Z.Y. Zhong*, Core-Crosslinked pH-Sensitive Degradable Micelles: A Promising Approach to Resolve the Extracellular Stability Versus Intracellular Drug Release Dilemma, J. Control. Release 2012, 164, 338-345.
18. C. Deng, Y.J. Jiang, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Biodegradable Polymeric Micelles for Targeted and Controlled Anticancer Drug Delivery: Promises, Progress and Prospects, Nano Today 2012, 7, 467-480 (invited review)
19. R.R. Wei, L. Cheng, M. Zheng, R. Cheng, F.H. Meng, C. Deng, and Z.Y. Zhong*, Reduction-Responsive Disassemblable Core-Cross-Linked Micelles Based on Poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)–Lipoic Acid Conjugates for Triggered Intracellular Anticancer Drug Release, Biomacromolecules 2012, 13, 2429-2438.
20. Y.F. Du, W. Chen, M. Zheng, F.H. Meng, and Z.Y. Zhong*, pH-Sensitive Degradable Chimaeric Polymersomes for the Intracellular Release of Doxorubicin Hydrochloride, Biomaterials 2012, 33, 7291-7299.