Synthesis of heterodimer radionuclide nanoparticles for magnetic resonance and single-photon emission computed tomography dual-modality imaging
a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, China
b Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
c School for Radiological and Interdisciplinary Sciences (RAD-X) & Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China
d Department of Radiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China
e Analysis and Testing Center, Soochow University, Suzhou, China
Nanoscale 2015, 7, 3392-3395
We report a facile synthesis of bifunctional Fe3O4-Ag125I heterodimers for use as dual-modality imaging agents in magnetic resonance (MR) and single-photon emission computed tomography (SPECT). We introduced 125I, which is a clinically used radioisotope, as a SPECT reporter, into Fe3O4-Ag heterodimer nanoparticles to provide a new type of bifunctional contrast agent for MRI and SPECT imaging.