Topic：Coordination Self-Assembly of Supramolecular Nano-Cages: Design, Modulation and Catalysis
Chemists are often inspired by the spontaneous and precise assembly of multiple protein subunits into giant well-defined functional superstructures. Metal-directed coordination self-assembled systems offer a controllable platform on a molecular level toward mimicking such biological process. Using this strategy, a series of giant host molecules have been successfully synthesized and characterized, including an unprecedented spherical M24L48 rombicuboctahedral nano-cage. Molecular level studies on these artificial multi-component self-assembled systems offers mechanistic insights into the massive biological self-assembly phenomena. Moreover, these artificial supramolecular hosts with confined inner space served as nanovessels for highly selective and efficient catalytic transformations. In this talk, we will discuss the design principles for the metal-directed coordination self-assembly, the reversible structural modulation based on a post-synthetic modification method, along with the enzymatic catalysis using a supramolecular M4L6 tetrahedral cage.
1) Qing-Fu Sun, Junji Iwasa, Dachi Ogawa, Yoshitaka Ishido, Sota Sato, Tomoji Ozeki, Yoshihisa Sei, Kentaro Yamaguchi, and Makoto Fujita*. “Self-assembled M24L48polyhedra and their sharp structural switch upon subtle ligand variation”. Science 328, 1144-1147, 2010.
2) Qing-Fu Sun, Sota Sato, and Makoto Fujita*. “An M18L24 stellated cuboctahedronthrough post-stellation of an M12L24 core”. Nature Chemistry 4, 330–333, 2012.
3) Qing-Fu Sun, Takashi Murase, Sota Sato, and Makoto Fujita*. “A sphere-insphere complex by orthogonal self-assembly”. Angew. Chem. Int. Ed. 50, 10318-10321,2011.
4) Shu-Yan Yu*, Qing-Fu Sun, Terence Kwok-Ming Lee, Eddie Chung-Chin Cheng, Yi-Zhi Li*, and Vivian Wing-Wah Yam*. “Au36 crown: metal-metal bonding interaction directed macrocyclization”. Angew. Chem. Int. Ed. 47, 4449-4554, 2008.