Topic：Rhodium-Catalyzed C-H Activation and Functionalization of Arenes: Scope, Selectivity, and Mechanism
Speaker： Researcher李兴伟 , DICP
Time：2014.3.19 pm 3:30 --- 5:00
Introduction to the speaker:
2001 – 2005 Ph. D (2005) and M. S. (2005) in inorganic chemistry, Yale University
Advisor: Robert H. Crabtree
1999 – 2001 Graduate study, State University of New York at Albany (school transferring to Yale)
1991 – 1996 B. S. (1996) in chemistry, Fudan University, China
2010-present Professor of Chemistry (the 100-Talent Program), Dalian Institute of Chemical Physics, Chinese Academyof Sciences
2008 – 2009 Assistant Professor of Catalysis, The Scripps Research Institute, Scripps Florida
2006 – 2008 Assistant Professor, Nanyang Technological University, Singapore
2005 – 2006 Postdoctoral Scholar, California Institute of Technology, advisor: John E. Bercaw
2012 Research Award, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
2005 Richard Wolfgang Prize for Best Ph. D. Thesis, Graduate School of Arts and
Sciences, Yale University
2002 Rhodium Bicentennial Fellowship from the Johnson Matthey Co.
2001 The Benjamin Smith Scholarship, State University of New York at Albany.
- Design of metal catalysts for new organic transformations
- Transition metal (rhodium and palladium) catalyzed oxidative C-C, C-O, and C-N coupling based on C-H activation
- Synthesis of heterocycles via metal catalyzed reaction methodologies
- Selective activation and oxidation of C-H bonds, oxidation of methane to methanol
- C-C coupling reactions involving alkynes.
- Alkyne and alkene hydroamination
- Anaerobic oxidation (dehydrogenation) of alcohols and other hydrogen-transfer reactions involving alcohols and amines.
(2) Synthetic organometallic chemistry
- Synthesis of metal complexes of Rh, Ir, Ru, Pt, and Pd, particularly with N-heterocyclic carbenes (NHC)
- Synthesis of complexes with abnormal binding modes of N-Heterocyclic Carbenes
- Synthesis and reactivity of protic N-heterocyclic carbenes
- Synthesis of late transition metal complexes featuring multi-dentate ligands with flexible binding modes.
- Structural and reactivity studies
(3) Mechanistic organometallic chemistry
- Inter- and intramolecular activation of C-H and C-C bonds.
- Metal-ligand cooperation/interactions in organometallic chemistry
- Hydrogen transfer reactions (hydrogenation, dehydrogenation, and transfer hydrogenation)
- Research methods: dynamic NMR spectroscopy, intermediate isolation, X-ray crystallography, isotope labeling, and reaction kinetics.
Metal-catalyzed C-H activation has been widely established as an important strategy in the functionalization of sp2 hybridized C-H bonds. In our studies, under oxidative or redox-neutral conditions, stable rhodium(III) complexes have been successfully applied to the C-H activation of arenes and olefins in the coupling with substrates such as alkenes, alkynes, strained rings, metal azides, and electrophilic amidating reagents. In these C-C and C-N coupling reactions, and Rh(III) catalysis has allowed the functionalization of a broad scope of arenes bearing a chelating group with high reactivity, broad substrate scope, and high functional group compatibility. The scope, selectivity, and mechanism of these reactions are discussed.