Nanopolymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo
Yan Zou1, Yaohua Wei1,2, Guanglin Wang3, Fenghua Meng*1（孟凤华）, Mingyuan Gao3, Gert Storm2, and Zhiyuan Zhong*1（钟志远）
1Biomedical Polymers Laboratory College of Chemistry Chemical Engineering and Materials Science ,Soochow University,Suzhou 215123, P.R. China
2Department of Biomaterials Science and Technology MIRA Institute for Biological Technology and Technical Medicine ,University of Twente PO Box 217, 7500AE Enschede, The Netherlands
3Center for Molecular Imaging and Nuclear Medicine School for Radiological and Interdisciplinary Sciences,Soochow University,Suzhou 215123, P.R. China
Adv. Mater.2017, 29, 1603997
Biocompatible and biodegradable nanopolymersomes with an unprecedented iodine content, low viscosity, and iso-osmolality achieve significantly enhanced CT imaging of blood pool and the reticuloendothelial system. Moreover, in subcutaneous and orthotopic tumor models in mice, they show enhanced in vivo imaging when compared to iohexol, a clinically used small-molecule contrast agent.