From the Chemistry of Poly(2-oxazoline)s to Their Use as Biomaterials

报告题目:From the Chemistry of Poly(2-oxazoline)s to Their Use as Biomaterials

报告人Prof. Richard Hoogenboom, Ghent University

时间:2018918日(星期二)上午 10:00-11:00

地点:独墅湖校区911406


CV:

Work experience: 2014.10–present, Full professor at Ghent University; 2010.7–2014.9,      Associate professor at Ghent University; 2009.9–2010.6, Senior postdoctoral researcher at the Radboud University Nijmegen, Institute for Molecules and Materials, Prof. Roeland Nolte; 2008.9–2009.8, Alexander von Humboldt postdoctoral fellow at the RWTH Aachen DWI, Prof. Martin Möller; 2005.11–2008.8, Project leader for the Dutch Polymer Institute (Prof. U. S. Schubert), and Senior product developer at Dolphys Medical BV.

Education: 1996.9–2001.10, MSc degree in Chemistry and Chemical Engineering (Supervisor: Prof. E. W. (Bert) Meijer), Eindhoven University of Technology; 2001.11–2005.11, PhD degree in Organic and Polymer Chemistry (Supervisor: Prof. U. S. Schubert), Eindhoven University of Technology.

Academic achievements: 1) 350 refereed scientific publications (> 200 as senior corresponding author; > 15,000 citations & h-index of 58); 13 patent applications (4 granted, 9 filed); 11 book chapters; 1 book edited. 2) (Co)promotor for 15 PhD theses (12 more ongoing) and 20 Master theses.3) 8 plenary lectures at conferences with multiple parallel sessions; > 65 invited lectures at international conferences, > 20 invited lectures at advanced schools.4) Associate editor for Australian Journal of Chemistry since 01/2012 and for European Polymer Journal since 01/2013.5) Member of the editorial boards of Mater. Today Chem., Polym. Chem., React. Funct. Polym., Macromol. Rapid Commun., Designed Monomers Polym., and Polymers. 6) Organizer of three symposia on Poly(2-oxazoline)s and pseudo-polypeptides at the ACS National meetings in San Diego 2012, San Francisco 2014 and Philadelphia 2016. 7) Regular reviewer for > 50 international journals, including Nature, Nat. Chem., Nat. Commun., Nat. Nanotechnol., Angew. Chem., JACS and Chem. Commun. 8) Elected panel member for ERC starting grants (2017), FWO Flanders (since 2013), and FCT in Portugal (2015) and the IRC in Ireland (2017-2018). 9) Attracted ~ 3,5 million euro of research funds in the past 5 years via competitive schemes. Major personal grants include the BOF-ZAP professorship at Ghent University (Belgium), Marie Curie Career Integration Grant (EU), Humboldt fellowship (Germany) and VENI-grant (Netherlands).  10) Fellow of the RSC and elected member of the Young Academy of Europe (YAE).

Awards: Inaugural 2015 Polymer Chemistry Lectureship award, 5th Polymer International IUPAC young investigator award (2016), Prometheus Award for Research from Ghent University (2016), ACS Macromolecules/Biomacromolecules young investigator award (2017).


Abstract:

The living cationic ring-opening polymerization of 2-oxazolines has been studied in great detail since its discovery in 1966. The versatility of this method allows copolymerization of a variety of 2-oxazoline monomers to give a range of tunable polymer properties that enable, for example, hydrophilic, hydrophobic, fluorophilic, as well as hard and soft materials. Moreover, the chemical versatility allows orthogonal end-group and side-chain modification of the polymers. However, this class of polymers was almost forgotten in the 1980s and 1990s because of the long reaction times and limited application possibilities. In the new millennium, a revival of poly(2-oxazoline)s has arisen because of their potential use as biomaterials and thermoresponsive materials, as well as the easy access to defined amphiphilic structures for (hierarchical) self-assembly (Figure 1).[1-3]  

Fig. 1 Structure of poly(2-oxazoline)s (middle) and schematic representation of their use as biomaterials.


Recent developments from our research group that illustrate the potential of poly(2-oxazoline)s will be discussed in this lecture, including the preparation of defined high-molar mass polymers [4] as well as functional biomaterials. Specific examples that will be discussed include the use of poly(2-oxazoline)s as pharmaceutical excipients,[5] evaluation of degradation and toxicity behaviour,[6] including pharmacokinetics,[7] as well as the preparation of various side-chain functionalized polymers and their use for the preparation of hydrogel cell scaffolds.[8,9]  

Within this lecture, the challenges that are posed by biomedical applications, such as defined materials with low toxicity and good biocompatibility, will be addressed based on improved synthetic methodologies and screening of in vitro and in vivo toxicity and faith of the materials.

All together, we aim to develop poly(2-oxazoline)s as biomaterials by providing in depth studies on the basic questions, such as biocompatibility and renal clearance as well as by providing proof of concept for use of poly(2-oxazoline)s for various specific applications.


References

[1] R. Hoogenboom, Angew. Chem., Int. Ed.2009, 48, 7978.

[2] O. Sedlacek, B. D. Monnery, S. K. Filippov, R. Hoogenboom, M. Hruby, Macromol. Rapid Commun. 2012, 33, 1648.

[3] R. Luxenhofer, Y. Han, A. Schulz, J. Tong, Z. He, A. V. Kabanov, R. Jordan, Macromol. Rapid Commun. 2012, 33, 1613.

[4] B. Monnery, R. Hoogenboom, EP 14177587.4.

[5] B. Claeys, A. Vervaeck, C. Vervaet, J. P. Remon, R. Hoogenboom, B. G. De Geest, Macromol. Rapid Commun. 2012, 33, 1701.

[6] H. P. C. Van Kuringen, J. Lenoir, E. Adriaens, J. Bender, B. G. De Geest, R. Hoogenboom, et al. Macromol. Biosci. 2012, 12, 1114.

[7] L. Wyffels, T. Verbrugghen, B. Monnery, M. Glassner, S. Stroobants, R. Hoogenboom, S. Staelens, J. Controlled Release2016, 235, 63.

[8] B. L. Farrugia, K. Kempe, U. S. Schubert, R. Hoogenboom, T. D. Dargaville, Biomacromolecules2013, 14, 2724.

[9] T. D. Dargaville, B. G. Hollier, A. Shokoomand, R. Hoogenboom, Cell Adhesion and Migration2014, 8, 88.


欢迎感兴趣的老师和同学参加。



                                                                              (报告联系人:赵优良老师)