Highly diastereo- and enantioselective organocatalytic addition of acetone to β-substituted α-ketoesters via dynamic kinetic resolution

Jin Yang, Ting Wang, Zhenhua Ding, Zongxuan Shen and Yawen Zhang*, Org. Biomol. Chem. 2009, 7, 2208–2213.

L-脯氨酸催化丙酮对β-取代α-酮酯的aldol反应，以良好产率、极好的非对映选择性 (up to >99:1 dr) 和对映选择性 (up to 98% ee) 给出所需加成产物. 用单晶X－衍射分析确定了手性加成产物的绝对构型。对反应的立体化学结果提出了推测性解释。