Cyanotrifluoromethylthiolation of unactivated dialkyl-substituted alkynes via cyano migration: synthesis of trifluoromethylthiolated acrylonitriles

Meishan Ji, Jiajia Yu and Chen Zhu ^*（朱晨）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China.

Chem. Commun., 2018, 54, 6812--6815

Herein a novel, elusive cyanotrifluoromethylthiolation of unactivated dialkyl-substituted alkynes is reported. Taking advantage of the intramolecular cyano migration strategy, the reaction proceeds stereoselectively to deliverE-olefinic products. A variety of tetrasubstituted trifluoromethylthiolated acrylonitriles are afforded in modest to good yields.

链接：http://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C8CC01189C#!divAbstract