报告题目：New Methods and Reagents for the Transition Metal-Free Direct Synthesis of Unprotected Aromatic Amines, Hydroxyarenes, Fused N-Heterocycles and Aziridines
The Kürti lab has been exploring several fundamentally new strategies and methods for the creation of novel C-C and C-heteroatom (C-O, C-N and C-S) bonds that expand the toolbox of synthetic organic chemists and enable the environmentally friendly (i.e., green) construction of complex molecular structures. A highly attractive, but currently underdeveloped, approach is the utilization of weak bonds (e.g., N-N, N-O) as a driving force to achieve the rapid formation of much stronger bonds under mild conditions.
During the past several years, the Kürti laboratory has successfully exploited these weak bonds and developed a number of transition-metal (TM)-free direct C-C, C-O and C-N bond-forming reactions, such as: (I) chiral acid-catalyzed atroposelective synthesis of functionalized biaryls; (II) direct arylation of arenes; (III) aerobic direct and regiospecific-arylation of ketones; (IV) low-temperature intramolecular C(sp2)-H amination of arenes; (V) the primary amination of arylboronic acids, primary/secondary amination as well as hydroxylation of aryl Grignard reagents (NATURE CHEMISTRY2017,http://www.nature.com/nchem/journal/vaop /ncurrent/full/nchem.2672. html), and (VI)double N-arylation of suitable electrophilic nitrogen linchpin reagents to afford N,N-diarylamines.
In addition his laboratory has played a crucial role in the discovery of the dirhodium-carboxylate-catalyzed direct and stereospecific synthesis of unprotected N-H and N-Me aziridinesfrom olefins (SCIENCE 2014, 343, 6166, 61-65) as well as the primary (-NH2) and NH-alkyl amination of arenes (SCIENCE 2016, 353, 6304, 1144-1147), transformations that eluded synthetic chemists for decades.
While still in graduate school he authored the now popular textbook/reference book "Strategic Applications of Named Reactions in Organic Synthesis" with Barbara Czakó that is now used in dozens of academic institutions and research laboratories worldwide.