Tertiary-Alcohol-Directed Functionalization of Remote C(sp3)@H Bonds by Sequential Hydrogen Atom and Heteroaryl Migrations
Xinxin Wu+, Mingyang Wang+, Leitao Huan, Dongping Wang, Jinwei Wang, and Chen Zhu*（朱晨）
Key Laboratory of Organic Synthesis of Jiangsu Province, College of
Chemistry, Chemical Engineering and Materials Science,Soochow University,199 Ren-Ai Road, Suzhou, Jiangsu 215123 (China)
[+] These authors contributed equally to this work.
Angew. Chem. Int. Ed.2018, 57, 1640--1644
Reported for the first time is a tertiary-alcohol-guided heteroarylation of remote C(sp3)−H bonds. The mild and direct generation of alkoxyl radicals from alcohols is enabled by visible-light photocatalysis. A remote hydrogen atom and heteroaryl migration sequence are involved in the reaction. Many sensitive groups remain intact in the reaction, thus illustrating wide functional-group compatibility. This protocol provides a practical strategy for the late-stage modification of alkyl ketones.
链接：http://onlinelibrary.wiley.com/doi/10.1002/anie.201709025/abstract
