严锋教授与上海交通大学王斌教授、复旦大学冒海蕾教授合作在Adv. Funct. Mater.上发表研究论文

Poly(ionic liquid)/Ce-Based Antimicrobial Nanofibrous  Membrane for Blocking Drug-Resistance Dissemination  from MRSA-Infected Wounds

Zhenhong Luo1,Hengqing Cui2,Jiangna Guo1,Jieran Yao3,Xia Fang2,Feng Yan1,4, *(严锋),Bin Wang2, *(王斌),Hailei Mao34, *(冒海蕾)


1 Soochow Univ, Coll Chem, Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

2 Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Shanghai 200011, Peoples R China

3 Fudan Univ, Zhongshan Hosp, Dept Anesthesiol & Crit Care Med, Shanghai 200032, Peoples R China

4 Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China


Adv. Funct. Mater.2021, 31, 2100336


Resistant bacteria have become a global threat. Even if bacteria are killed, their carried drug-resistant genes can remain in the environment and spread to other microbes via horizontal gene transfer. Development of antimicrobial materials with intrinsic gene break down activity can prevent the dissemination of released drug-resistant genes from the dead bacteria. Herein, imidazolium type poly(ionic liquid) (PIL)/cerium (IV) ion-based electrospun nanofibrous membranes (PIL-Ce) are synthesized. The effects of PIL and Ce moieties on the antimicrobial properties against Gram-negative Escherichia coli and kanamycin-resistant E. coli, and Gram-positive Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), as well as deoxyribonuclease-mimic activities to the drug-resistant genes of KanR (E. coli) and mecA (MRSA) are investigated. The Ce-containing PIL membranes show the high efficiencies to eradicate bacteria and disintegrate drug-resistant genes. A wound treatment test using MRSA infected mice as the model further demonstrate that PIL-Ce membranes combine both antibacterial and DNase-mimic properties, and may have the potential application as a new “green” wound dressing to block the drug resistance spread in a clinical setting.


链接:https://onlinelibrary.wiley.com/doi/10.1002/adfm.202100336