 | 姓名：徐新芳 职称：教授、博士生导师 部门：化学学院 联系方式： 0512-65883612 Email: xinfangxu@suda.edu.cn 地址：苏州工业园区仁爱路199号701号楼B606室 邮编：215123 课题组网站 |
学历及学术经历 2005年毕业于华东师范大学，获学士学位；同年直升本校研究生，硕博连读，2010年获博士学位（导师：胡文浩教授，杨琍苹教授）；期间2007年9月-12月，中国科学技术大学交流学习（导师：龚流柱教授）。2010年8月至2014年9月美国马里兰大学博士后研究（导师：Michael P.Doyle教授)。2014年9月回国，任苏州大学材料与化学化工学部特聘教授、博士生导师。 研究工作和成果 近五年来，一直在金属卡宾化学的催化反应相关领域开展研究工作，从事新的合成方法学的发现，选择性催化研究，特别是不对称催化反应研究和杂环类化合物的高效合成，取得了一系列独创性的研究成果。迄今为止，已在国际核心期刊上发表SCI论文近30篇，第一或通讯作者20余篇。最近五年接连在Acc. Chem. Res. (1篇)，Angew. Chem. Int. Ed. (5篇)，J. Am. Chem. Soc. (3篇), Chem. Comm.（5篇），Org. Lett., Chem. Eur. J.，等权威期刊发表多篇一作研究论文，论文他引400余次。其中六篇研究论文被专业有机评论杂志Synfacts 评述，得到了国际同行的高度评价和广泛关注。 研究领域：不对称催化；金属卡宾反应；环丙烯化学；金属卡宾串联反应；多组分反应；多功能团杂环化合物和生物活性分子的高效合成；药物及其中间体的合成和工艺研究。 招生方向: 本课题组在有机合成和金属催化领域具有良好的实验条件，欢迎相关专业的本科生和硕士生报考，欢迎本科生提前来课题组参加带薪科研和完成毕业论文。 近期代表性论文 (*通讯作者) 1. The [3+3]-Cycloaddition Alternative for Heterocycle Syntheses: Catalytically Generated Metalloenolcarbenes as Dipolar Adducts, Xinfang Xu and Michael P. Doyle*, Acc. Chem. Res., 2014, 47, 1396-1405. 2. Highly Diasteroselective Intermolecular 1,3-Dipolar Cycloaddition Reactions of Carbonyl Ylides with Aldimines to Afford Sterically Disfavored cis-Oxazolidines, Xinfang Xu, Xin Guo, Xingchun Han, Liping Yang and Wenhao Hu*, Org. Chem. Front., 2014, 1, 181-185. 3. Recent Developments in the Synthetic Uses of Silyl-protected Enoldiazoacetates for Heterocyclic Syntheses, Xinfang Xu* and Michael P. Doyle*, Aust. J. Chem.2014, 67, 365-373. 4. Highly Enantioselective Dearomatizing Formal [3+3]-Cycloaddition Reactions of N-Acyliminopyridinium Ylides with Electrophilic Enolcarbene Intermediates, Xinfang Xu,Peter Y. Zavalij, and Michael P. Doyle*, Angew. Chem. Int. Ed., 2013, 52, 12664-12668. 5.A Donor-acceptor Cyclopropene as a Dipole Source for a Silver(I) Catalyzed Asymmetric Catalytic [3+3]-Cycloaddition with Nitrones,Xinfang Xu,Peter Y. Zavalij, and Michael P. Doyle*,Chem. Commun., 2013, 49, 10287-10289. 6. Simple and Sustainable Iron-Catalyzed Aerobic C-H Functionalization of N,N Dialkylanilines,Maxim O. Ratnikov,Xinfang Xu, and Michael P. Doyle*, J. Am. Chem. Soc., 2013, 135, 9475-9479 (Article). 7. Dirhodium(II)-Catalyzed Formal [3+2+1]-Annulation of Azomethine Imines with Two Molecules of a Diazo Ketone,Xinfang Xu, Xichen Xu, Peter Y. Zavalij, and Michael P. Doyle*,Chem. Commun., 2013, 49, 2762-2764. 8.Vinylogous Reactivity of Enol Diazoacetates with Donor–Acceptor Substituted Hydrazones. Synthesis of Substituted Pyrazole Derivatives,Xinfang Xu, Peter Y. Zavalij, Wenhao Hu, and Michael P. Doyle*, J. Org. Chem., 2013, 78, 1583-1588 (Article). 9.Synthesis of Tetrahydropyridazines by a Metal–Carbene-Directed Enantioselective Vinylogous N-H Insertion/Lewis Acid-Catalyzed Diastereoselective Mannich Addition,Xinfang Xu,Peter Y. Zavalij, and Michael P. Doyle*, Angew. Chem. Int. Ed., 2012, 51, 9829-9833.（Reviewed by Synfacts: 2012, 8,1181） 10.Rhodium(II)- and Copper(II)-Catalyzed Reactions of Enol Diazoacetates with Nitrones: Metal Carbene versus Lewis Acid Directed Pathways, Yu Qian,Xinfang Xu, Xiaochen Wang, Peter Y. Zavalij, Wenhao Hu, and Michael P. Doyle*,Angew. Chem. Int. Ed., 2012, 51, 5900-5903. （Reviewed by Synfacts: 2012, 8,0861） 11.Efficient Synthesis of Oxazoles by Dirhodium(II)-catalyzed Reactions of Styryl diazoacetate with Oximes,Xinfang Xu,Peter Y. Zavalij, Wenhao Hu, and Michael P. Doyle*,Chem. Commun., 2012, 48, 11522-11524. 12.Unexpected Catalytic Reactions of Silyl-Protected Enol Diazoacetates with NitrileOxides That Form 5-Arylaminofuran-2(3H)-one-4-carboxylates,Xinfang Xu, Dmitry Shabashov, Peter Y. Zavalij, and Michael P. Doyle*,Org. Lett., 2012, 14, 800-803. 13.Substrate-Dependent Divergent Outcomes from Catalytic Reactions of Silyl-Protected Enol Diazoacetates with Nitrile Oxides: Azabicyclo[3.1.0]hexanes or 5-Arylaminofuran-2(3H)-ones,Xinfang Xu, Dmitry Shabashov, Peter Y. Zavalij, and Michael P. Doyle*,J. Org. Chem., 2012, 77, 5313-5317 (Article). 14.Divergent Outcomes of Carbene Transfer Reactions from Dirhodiumand Copper-Based Catalysts Separately or in Combination,Xinfang Xu, Wenhao Hu, Peter Y. Zavalij, and Michael P. Doyle*,Angew. Chem. Int. Ed., 2011, 50, 11152-11155. （Reviewed by Synfacts: 2011, 9,0976） 15.Highly Enantioselective Catalytic Synthesis of Functionalized Chiral Diazoacetoacetates,Xinfang Xu, Wenhao Hu, and Michael P. Doyle*,Angew. Chem. Int. Ed., 2011, 50, 6392-6395. 16.Asymmetric Formal [3 + 3]-Cycloaddition Reactions of Nitrones with Electrophilic Vinylcarbene Intermediates, Xiaochen Wang,Xinfang Xu,Peter Y. Zavalij, and Michael P. Doyle*,J. Am. Chem. Soc., 2011, 133, 16402-16405. 17.Cooperative Catalysis in Highly Enantioselective Mannich-type Three-component Reaction of a Diazoacetophenone with an Alcohol and an Imine,Xinfang Xu, Yu Qian, Liping Yang, and Wenhao Hu*,Chem. Commun., 2011, 47, 797-799. （Reviewed by Synfacts: 2011, 3,0304） 18.Multifunctionalized 3-Hydroxypyrroles in a Three-Step, One-Pot Cascade Process from Methyl 3-TBSO-2-diazo-3-butenoate and Nitrones,Xinfang Xu, Maxim O. Ratnikov, Peter Y. Zavalij, and Michael P. Doyle*,Org. Lett., 2011, 13, 6122-6125. 19.A Strategy to Synthesize Taxol Side Chain and (-)-epi Cytoxazone via Chiral Brønsted Acid-Rh2(OAc)4 Co-catalyzed EnantioselectiveThree-Component Reactions, Yu Qian, Xinfang Xu, Liqin Jiang, Dipak Prajapati, and Wenhao Hu*,J. Org. Chem., 2010, 75, 7483-7486. 20.Highly Diastereoselective Synthesis of Fully Substituted Tetrahydrofurans by a One-Pot Cascade Reaction of Aryldiazoacetates with Allyl Alcohols,Xinfang Xu, Xinchun Han, Liping Yang, and Wenhao Hu*,Chem. Eur. J., 2009, 15, 12604-12607.（Reviewed by Synfacts: 2010, 2, 0186） 21.Cooperative Catalysis with Chiral Brønsted Acid-Rh2(OAc)4: Highly Enantioselective Three-Component Reactions of Diazo Compounds with Alcohols and Imines, Wenhao Hu*,Xinfang Xu, Jing Zhou, Weijun Liu, Haoxi Huang, Juan Hu, Liping Yang, and Liuzhu Gong*, J. Am. Chem. Soc., 2008, 130, 7782-7783. 22.Selectivity Control in Enantioselective Four-component Reactions of Aryl Diazoacetates with Alcohols, Aldehydes and Amines: an Efficient Approach to Synthesizing Chiral -Amino--hydroxyesters,Xinfang Xu, Jing Zhou, Liping Yang, and Wenhao Hu*, Chem. Commun., 2008, 44, 6564-6566.（Reviewed by Synfacts: 2009, 2, 0173） | |
