严锋教授与郭江娜博士合作在 Biomacromolecules 上发表研究论文

Fluorescent Imidazolium-Type Poly(ionic liquid)s for Bacterial Imaging and Biofilm Inhibition

Mengyao Wang, Jie Shi, Hailei Mao, Zhe Sun, Siyu Guo, Jiangna Guo*,†(郭江娜), and Feng Yan*,†(严锋)

  

Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Department of Anesthesiology and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200438, China

  

Biomacromolecules 2019, 20, 3161--3170

  

Fluorescent imidazolium-type poly(ionic liquid)s (PIL)s were synthesized by anion exchange of bromide (Br) in poly(3-butyl-1-vinylimidazolium bromide) (PIL-Br) with a fluorescent anion, namely, 3-(4-(1,2,2-triphenylvinyl)phenoxy)propane-1-sulfonate (TPESO3). Such an anion exchange provided antibacterial PILs with aggregation-induced emission (AIE) properties that simultaneously kill and image bacteria. These fluorescence and antibacterial properties could be regulated by controlling the Br/TPESO3 ratio. The fluorescence intensity increases as this ratio increases, while the antibacterial property exhibits an opposite trend. Moreover, the AIE-type PILs are useful for fluorescently imaging dead bacteria (macroscopically and microscopically) and could effectively inhibit biofilm growth. This study provided a convenient method to obtain fluorescent PILs with adjustable antibacterial and imaging properties.

  

  

链接:https://pubs.acs.org/doi/10.1021/acs.biomac.9b00741