报告题目: Macromolecular Design of Functional Polymeric Materials using Cyclic Imino Ethers
报告人: Dr. Kristian Kempe
Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia
报告时间: 2018年11月7日（星期三）下午 14:00-15:00
报告地点:独墅湖校区909号楼3403室
报告摘要: Cyclic imino ethers (CIEs) are a unique class of monomers, which can be polymerised via multiple techniques (Figure 1). Five and six membered CIEs, also better known as oxazolines and oxazines are potent monomers in living cationic ring-opening polymerisations (CROP). Through the choice of suitable substituted monomers, initiators, and terminating agents, well-defined functional poly(2-oxazoline)s (POx) and poly(2-oxazine)s are obtained which can be tailored for a range of applications. In particular poly(2-methyl-2-oxazoline) (PMeOx) and poly(2-ethyl-2-oxazoline) (PEtOx) have attracted significant attention in the last decades owing to their excellent biocompatibility and antifouling and stealth properties.
An alternative approach to prepare CIE based polymers is the spontaneous zwitterionic copolymerisation (SZWIP). Zwitterionic polymerisations are ionic polymerisations which proceed via zwitterionic propagating species. The SZWIP is believed to occur via a zwitterionic intermediate which is formed upon the reaction between an electrophilic (ME) and nucleophilic monomer (MN) without the addition of an initiator or catalyst. CIEs have been shown to be powerful MNs reacting with diverse MEs such as acrylic acid and anhydrides. Unsaturated carboxylic acids and their derivatives have attracted significant attention as functional MEs as they provide access to poly(ester amide)s, more specifically N-acylated poly(aminoester)s (NPAEs).
In this presentation the potential of CIEs for the preparation of functional biocompatible and biodegradable materials will be discussed to highlight the enormous potential they offer for future applications in nanomedicine and beyond. Particular focus will lie on the modularity of POx, the fabrication of nano- and micron-sized POx particles and the introduction of the SZWIP for the facile synthesis of functional NPAEs.
报告人简介：Dr. Kristian Kempe studied chemistry at the Friedrich-Schiller-University Jena (Germany) and the Eindhoven University of Technology (The Netherlands). In 2010 he was a visiting researcher in the group of Prof. Craig J. Hawker (University of California, Santa Barbara) before he completed his Ph.D. at the end of 2011 under the supervision of Prof. Ulrich S. Schubert in Jena. In 2012 he received a prestigious Alexander von Humboldt-fellowship to conduct research in the groups of Prof. Frank Caruso (The University of Melbourne) and Prof. David M. Haddleton/ Prof. Thomas P. Davis (Monash University). In mid-2014 he was appointed to the position of Senior Research Fellow at the University of Warwick to work alongside Prof. David M. Haddleton. Currently, he is a Group Leader and NHMRC-ARC Dementia Research Fellow at the Monash Institute of Pharmaceutical Sciences, Monash University.
To date, he has co-authored more than 100 publications in high impact polymer and materials science journals (h-index 34). His current research interests include, ‘smart’ responsive macromolecules, biocompatible and biodegradable polymers, poly(2-oxazoline)s, efficient polymer modification reactions, polymer-peptide conjugation strategies and the design of functional particle systems and hydrogels for applications in nanomedicine and material science with particular focus on brain drug delivery.
（报告联系人：钟志远老师课题组）
