报告题目：Biostable Polyurethanes for Medical Applications
报告人：Prof. Rudolf Faust
University of Massachusetts-Lowell
报告时间：9月6日（星期五）下午 3：00
报告地点：912-1114
报告摘要：
Polyether based thermoplastic polyurethanes (TPUs) have been widely used in biomedical applications due to a broad range of desirable properties. However, these polymers are highly susceptible to oxidative degradation leading to a deterioration of mechanical properties. Polyisobutylene (PIB) is well known for its superior biostability and biocompatibility as many PIB copolymers have been studied for various biomedical applications. We have investigated the preparation of PIB based based TPUs by a two-step solution-based synthesis. The tensile strength of the prepared TPUs were still inferior compared to polyether based TPUs, however, addition of a small amount of polyether diol dramatically increased the tensile strength and ultimate elongation, while not affecting the biostability. Commercial applications of PIB TPUs are limited since the precursor PIB diol, obtained by living cationic polymerization, is not available commercially. Therefore we have also studied the preparation of poly(ethylene-butylene) (PEB) based TPUs as the PEB diol, made by living anionic polymerization, is commercially available. Similarly to PIB TPUs the addition of a small amount (20 w%) of poly(tetramethylene oxide) diol was necessary to obtain TPUs with excellent mechanical properties (tensile strength up to 32 MPa, ultimate elongation up to 830%). In vitro accelerated metal ion oxidative degradation studies were carried out in 20% H2O2 solution containing 0.1 M CoCl2 at 50 °C for 12 weeks. After 12 weeks the PEB TPU retained 90% of its weight, 79% of tensile strength and 85% of ultimate elongation, indicating superior stability, similar to PIB based TPUs.
个人简介：
Rudolf Faust is Professor of chemistry at the University of Massachusetts Lowell. He received his Diploma in Chemistry in 1975, and Ph.D. in Colloid Chemistry in 1978 from Eotvos Lorand University, Budapest, Hungary.Subsequently, he was a Visiting Scientist, at the Institute of Polymer Science, The University of Akron, before joining the University of Massachusetts Lowell (formerly University of Lowell) in 1988.Faust pioneered living carbocationic polymerization of hydrocarbon olefins and has made important contributions in macromolecular engineering i.e., the preparation of well-defined polymers with controlled architecture, molecular weight, molecular weight distribution and end-functionalities. He is the recipient of the Mark Milkovich Memorial Lecture Award (University of Akron, 2006), the Chemistry of Thermoplastic Elastomers Award (Rubber Division, American Chemical Society, 2010), and was elected fellow of the National Academy of Inventors (2015). He holds 36 U.S. patents, published more than 260 articles, 5 book chapters/books and serves on the editorial board of Polymer Bulletin and the Journal of Macromolecular Science.
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