Intramolecular nitration–aminocarbonylation of unactivated olefins: metal-free synthesis of c-lactams

Dong Chen, Meishan Ji and Chen Zhu^*（朱晨）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China.

Chem. Commun.,2019,55, 7796--7799

Disclosed herein is a novel, metal-free synthesis of γ-lactams through the radical-mediated nitration–aminocarbonylation of unactivated olefins. The reaction is initiated by a nitro radical generated from the homolysis of tert-butyl nitrite. The intramolecular cyanamide serves as the aminocarbonylating reagent. This protocol offers an environment-benign method to produce the synthetically valuable nitromethyl substituted γ-lactams.

链接：https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC03736E#!divAbstract