朱晨教授在 Org. Lett. 上发表研究论文

Regioselective Sulfonylvinylation of the Unactivated C(sp3 )−H Bond via a C‑Centered Radical-Mediated Hydrogen Atom Transfer (HAT) Process

Shan Yang, Xinxin Wu, Shuo Wu, and Chen Zhu*,†,‡(朱晨)

  

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, People’s Republic of China

Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People’s Republic of China

  

Org. Lett.2019, 21, 4837--4841

  

Given the similarity of multiple sp3 C–H bonds in electronic properties and bond dissociation energy (BDE), regioselective sp3 C–H bond functionalization remains a paramount challenge. Here, we report a C-centered radical-mediated approach for site-specific sulfonylvinylation of the C(sp3)–H bond via the hydrogen atom transfer (HAT) process. The reaction features mild conditions, broad substrate scope, and high regioselectivity and stereoselectivity, manifesting the nontrivial synthetic potential.

  

  

链接:https://pubs.acs.org/doi/10.1021/acs.orglett.9b01734